Does understanding endotypes translate to better asthma management options for all?

Arginine metabolic endotypes related to asthma severity

AIMS Arginine metabolism via inducible nitric oxide synthase (iNOS) and arginase 2 (ARG2) is higher in asthmatics than in healthy individuals. We hypothesized that a sub-phenotype of asthma might be defined by the magnitude of arginine metabolism categorized on the basis of high and low fraction of exhaled nitric oxide (FENO). METHODS To test this hypothesis, asthmatics (n = 52) were compared...

Endotypes of Asthma in Children

Asthma is a syndrome that includes several disease variants. Definition of asthma is a chronic disorder of the lung with variable airway obstruction, wheeze/cough, and an underlying inflammatory process with remodeling. It appears that atopic genes are not necessarily directly related to childhood asthma. Airway epithelial cells express genes that encode proteins directly related to asthma. Mat...

Asthma Endotypes and an Overview of Targeted Therapy for Asthma

Guidelines for the management of severe asthma do not emphasize the measurement of the inflammatory component of airway disease to indicate appropriate treatments or to monitor response to treatment. Inflammation is a central component of asthma and contributes to symptoms, physiological, and structural abnormalities. It can be assessed by a number of endotyping strategies based on "omics" tech...

Asthma phenotypes and endotypes: a personalized approach to treatment.

PURPOSE OF REVIEW Asthma is quite common and is better described as a syndrome with a heterogeneous presentation than as a single disease. Although most individuals can be effectively managed using a guideline-directed approach to care, those with the most severe illness may benefit from a more targeted therapy. The review describes our current understanding of how asthma phenotypes (observable...

How Does Systran Translate ?